Pathogenesis of maternal-fetal syphilis revisited.

  title={Pathogenesis of maternal-fetal syphilis revisited.},
  author={Victoria Wicher and K J Wicher},
  journal={Clinical infectious diseases : an official publication of the Infectious Diseases Society of America},
  volume={33 3},
Although congenital syphilis has been recognized for several centuries and an efficient treatment with penicillin became available more than a half-century ago, the disease is still with us. Inability to culture in vitro the causative agent, Treponema pallidum, and the lack of an adequate animal model have prevented exploration of the various immunopathological events affecting the natural course of congenital infection. The purpose of this review is to analyze the disease in the context of… CONTINUE READING