Pathogenesis of liver fibrosis: role of oxidative stress.

  title={Pathogenesis of liver fibrosis: role of oxidative stress.},
  author={Giuseppe Poli},
  journal={Molecular aspects of medicine},
  volume={21 3},
In the liver, the progressive accumulation of connective tissue, a complex and dynamic process termed fibrosis, represents a very frequent event following a repeated or chronic insult of sufficient intensity to trigger a "wound healing"-like reaction. The fibrotic process recognises the involvement of various cells and different factors in bringing about an excessive fibrogenesis with disruption of intercellular contacts and interactions and of extracellular matrix composition. However, Kupffer… CONTINUE READING
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