Pathogenesis of isoproterenol-induced myocardial lesions: its reation to human 'coagulative myocytolysis'.

@article{Milei1978PathogenesisOI,
  title={Pathogenesis of isoproterenol-induced myocardial lesions: its reation to human 'coagulative myocytolysis'.},
  author={Jos{\'e} Milei and R G N{\'u}{\~n}ez and Mark Rapaport},
  journal={Cardiology},
  year={1978},
  volume={63 3},
  pages={139-51}
}
Animals develop 'infarct-like' lesions when injected with isoproterenol (ISP), a potent synthetic catecholamine. These lesions are morphologically similar to those of 'coagulative myocytolysis' (COAM) or myofibrillar degeneration, one of the findings described in acute myocardial infarction and sudden death in man. Wistar rats were divided into 8 groups: some were injected with 10 mg/kg ISP i.p. plus 5 muCi of tritiated ISP, while others served as control. Animals were sacrified at 5 and 30 min… CONTINUE READING

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