Pathogenesis of in utero infections with abortogenic and non-abortogenic alphaviruses in mice.

@article{Milner1984PathogenesisOI,
  title={Pathogenesis of in utero infections with abortogenic and non-abortogenic alphaviruses in mice.},
  author={Andrew R. Milner and I. D. Marshall},
  journal={Journal of virology},
  year={1984},
  volume={50 1},
  pages={66-72}
}
The initial stages of infection of pregnant mice at gestation day 11 with either the T48 strain of Ross River virus or avirulent Semliki Forest virus are similar. With both infections, a hematogenous spread of virus to the placenta occurs. The viruses subsequently replicate to high titer in all placentas and are able to persist in the presence of specific maternal antiviral antibodies. There is a delay of at least 1 to 2 days between the initial detection of virus in the placenta and the onset… CONTINUE READING