Pathogenesis of heparin-induced thrombocytopenia

  title={Pathogenesis of heparin-induced thrombocytopenia},
  author={Yves Gruel and Claire Pouplard},
Heparin-induced thrombocytopenia (HIT), is a unique model of immune-mediated disorder due to the development of antibodies (mainly IgG) specific to platelet factor 4 (PF4). PF4 is a C-X-C chemokine present in platelet alpha granules and released in plasma as tetramers that exposed an electropositive ring critical for the binding of heparin, a negatively-charged molecule. PF4-heparin interactions induce the expression of neoepitopes involving several aminoacids (including P37, R49, L55 and K61… CONTINUE READING