Subsequent experiments were carried out on rats. In the animals of group 2 of this series, the activity of the RES was modified by application of an electric current. This stimulus depresses the activity of the reticuloendothelium . For a period of one week before administration of the hemolytic poison and during the same period thereafter, an alternating electric current of vottage 40 V was applied daily to the rats for 10-16 min. Observations were made on 10 animals. Control rats received only phenylhydrazine. The dose of the hemolytic poison was 20 mg/kg.