Pathogenesis of gastroesophageal reflux and Barrett esophagus.

  title={Pathogenesis of gastroesophageal reflux and Barrett esophagus.},
  author={Navtej S. Buttar and Gary W. Falk},
  journal={Mayo Clinic proceedings},
  volume={76 2},
Barrett esophagus is a metaplastic condition that affects the lower esophagus and is a complication of gastroesophageal reflux disease (GERD). Under normal circumstances, the reflux of gastric contents into the esophagus is prevented by a complex barrier at the esophagogastric junction. Dysfunction of the lower esophageal sphincter and the presence of a hiatal hernia lead to failure of this barrier. Esophageal mucosal damage results from the chronic exposure of the esophageal mucosa to… CONTINUE READING