Pathogenesis of experimental Ebola Zaire virus infection in BALB/c mice.

@article{Gibb2001PathogenesisOE,
  title={Pathogenesis of experimental Ebola Zaire virus infection in BALB/c mice.},
  author={Tammy R Gibb and Mike Bray and Thomas W. Geisbert and Keith E. Steele and Wayne M Kell and Kelly J. Davis and Nancy K Jaax},
  journal={Journal of comparative pathology},
  year={2001},
  volume={125 4},
  pages={233-42}
}
Guinea-pigs and non-human primates have traditionally been used as animal models for studying Ebola Zaire virus (EBO-Z) infections. The virus was also recently adapted to the stage of lethal virulence in BALB/c mice. This murine model is now in use for testing antiviral medications and vaccines. However, the pathological features of EBO-Z infection in mice have not yet been fully described. To identify sites of viral replication and characterize sequential morphological changes in BALB/c mice… CONTINUE READING