Pathogenesis of disseminated intravascular coagulation in sepsis.

@article{Levi1993PathogenesisOD,
  title={Pathogenesis of disseminated intravascular coagulation in sepsis.},
  author={Marcel M. Levi and Hugo Ten Cate and Tom van der Poll and Sander J.H. van Deventer},
  journal={JAMA},
  year={1993},
  volume={270 8},
  pages={975-9}
}
OBJECTIVE To review new insights in the pathogenetic mechanisms involved in the development of disseminated intravascular coagulation (DIC) in septic patients, in order to develop new directions for therapeutic intervention. DATA SOURCES Articles and published peer-reviewed abstracts on the mechanism of the initiation of DIC in sepsis. STUDY SELECTION Studies selected for detailed review were those reporting specifics about the mechanism of activation of coagulation and fibrinolysis in… CONTINUE READING