Pathogenesis of degenerative retinopathies induced by thioridazine and other antipsychotics: a dopamine hypothesis

@article{Fornaro2004PathogenesisOD,
  title={Pathogenesis of degenerative retinopathies induced by thioridazine and other antipsychotics: a dopamine hypothesis},
  author={Pantaleo Fornaro and Giovanni Calabria and Guido Corallo and Giovanni B. Picotti},
  journal={Documenta Ophthalmologica},
  year={2004},
  volume={105},
  pages={41-49}
}
Thioridazine and other antipsychotics (neuroleptics, dopaminergic antagonists) can cause degenerative retinopathies with histological, electrophysiological and symptomatological features similar to those of primary retinitis pigmentosa. It was formerly suggested that these retinopathies are due to drug absorption by melanin of the eye which damages the choriocapillaris first and subsequently the photoreceptors and the retinal pigment epithelium. An alternative explanation of the still unclear… 
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