Pathogenesis of cyclosporine nephropathy: roles of angiotensin II and osteopontin.

  title={Pathogenesis of cyclosporine nephropathy: roles of angiotensin II and osteopontin.},
  author={Raimund H Pichler and Nora Franceschini and Bradford A. Young and Christian P. M. Hugo and Takeshi F Andoh and Emmanuel de Almeida Burdmann and Stuart J. Shankland and Charles E. Alpers and W. M. Bennett and William G. Couser},
  journal={Journal of the American Society of Nephrology : JASN},
  volume={6 4},
Low-salt-diet, cyclosporine (CsA; 15 mg/kg per day)-treated rats develop striped interstitial fibrosis, arteriolar hyalinosis, and azotemia similar to the chronic nephropathy observed in humans. To examine the role of angiotensin II in this model, rats on a low-salt diet were given CsA, CsA and the angiotensin II receptor Type I antagonist Losartan (10 mg/kg per day), CsA and hydralazine/furosemide, or vehicle. At Day 35, CsA-treated rats had tubular injury, arteriolopathy of the afferent… CONTINUE READING