Pathogenesis of central and complex sleep apnoea.

  title={Pathogenesis of central and complex sleep apnoea.},
  author={Jeremy E Orr and Atul Malhotra and Scott A. Sands},
  volume={22 1},
Central sleep apnoea (CSA) - the temporary absence or diminution of ventilatory effort during sleep - is seen in a variety of forms including periodic breathing in infancy and healthy adults at altitude and Cheyne-Stokes respiration in heart failure. In most circumstances, the cyclic absence of effort is paradoxically a consequence of hypersensitive ventilatory chemoreflex responses to oppose changes in airflow, that is elevated loop gain, leading to overshoot/undershoot ventilatory… CONTINUE READING
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