Pathogenesis of autoimmunity after xenogeneic thymus transplantation.

@article{Yan2001PathogenesisOA,
  title={Pathogenesis of autoimmunity after xenogeneic thymus transplantation.},
  author={Yehong Yan and Timothy Devos and Lisong Yu and Guliang Xia and O Mer Rutgeerts and J Ozef Goebels and Constant Segers and Yuan Lin and Michel Vandeputte and Mark Prof Dr Waer},
  journal={Journal of immunology},
  year={2001},
  volume={170 12},
  pages={
          5936-46
        }
}
Thymus transplantation is a promising strategy to induce xenotolerance, but may also induce an autoimmune syndrome (AIS). The pathogenesis of this AIS was explored using nude rats as recipients. Thymus grafts consisted of fetal hamster thymic tissue with or without mixing with fetal rat tissue such as thymus, thyroid, salivary gland, and heart. All hamster thymus recipients died of AIS within 2-3 mo. In most recipients of xenothymus mixed with rat tissues such as thymus, thyroid, and salivary… CONTINUE READING
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