Pathogenesis of arterial lesions induced by dopaminergic compounds in the rat.

@article{Kerns1989PathogenesisOA,
  title={Pathogenesis of arterial lesions induced by dopaminergic compounds in the rat.},
  author={William David Kerns and Elisa Arena and Richard A. Macia and Peter J. Bugelski and William D. Matthews and Daniel G. Morgan},
  journal={Toxicologic pathology},
  year={1989},
  volume={17 1 Pt 2},
  pages={
          203-13
        }
}
Fenoldopam mesylate (FM), a selective post-junctional dopaminergic (DA1) vasodilator, causes lesions of large caliber splanchnic arteries (100-800 microns) in the rat characterized by necrosis of medial smooth muscle cells and hemorrhage. FM does not induce lesions in other vascular beds of the rat, or in dogs or monkeys. Dopamine, like FM, causes hemorrhagic lesions of large caliber splanchnic arteries in the rat, as well as fibrinoid necrosis of small caliber arteries (less than 100 microns… CONTINUE READING
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