Pathogenesis of antiphospholipid syndrome: understanding the antibodies

  title={Pathogenesis of antiphospholipid syndrome: understanding the antibodies},
  author={Pier Luigi Meroni and Maria O Borghi and Elena Raschi and Francesco Saverio Tedesco},
  journal={Nature Reviews Rheumatology},
Antiphospholipid antibodies (aPL) are both diagnostic markers for, and pathogenic drivers of, antiphospholipid syndrome (APS). Although the presence of aPL is a necessary pre-condition, APS-associated clotting is seemingly triggered by an additional 'second hit', frequently related to innate inflammatory immune responses. β2 glycoprotein I (β2GPI)-dependent aPL, the most important subset of these antibodies, mediate several—not necessarily alternative—thrombogenic mechanisms, mainly on the… CONTINUE READING
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