Pathogenesis of XJ and Romero strains of Junin virus in two strains of guinea pigs.

@article{Yun2008PathogenesisOX,
  title={Pathogenesis of XJ and Romero strains of Junin virus in two strains of guinea pigs.},
  author={Nadezhda E. Yun and Nathaniel Seth Linde and Natallia Dziuba and Michele A Zacks and Jeanon N. Smith and Jennifer K. Smith and Judy F Aronson and Olga V Chumakova and Heather M Lander and Clarence J. Peters and Slobodan Paessler},
  journal={The American journal of tropical medicine and hygiene},
  year={2008},
  volume={79 2},
  pages={275-82}
}
Argentine hemorrhagic fever (AHF), a systemic infectious disease caused by infection with Junin virus, affects several organs, and patients can show hematologic, cardiovascular, renal, or neurologic symptoms. We compared the virulence of two Junin virus strains in inbred and outbred guinea pigs with the aim of characterizing this animal model better for future vaccine/antiviral efficacy studies. Our data indicate that this passage of the XJ strain is attenuated in guinea pigs. In contrast, the… CONTINUE READING