Pathogenesis of Sjögren's syndrome.

  title={Pathogenesis of Sj{\"o}gren's syndrome.},
  author={Robert Irving Fox and Hee I Kang},
  journal={Rheumatic diseases clinics of North America},
  volume={18 3},
Sjögren's syndrome is a systemic autoimmune disease characterized by lymphocytic infiltrations of lacrimal and salivary glands. SS patients produce a variety of autoantibodies, including RF and ANA. Genetic factors, including HLA-DR3, predispose to primary SS. In contrast to normal SGs, the SS SG epithelial cells express high levels of HLA-DR antigens. This class II gene expression on the target organ may represent the structural basis for HLA-associated disease susceptibility. The glands are… CONTINUE READING


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