Pathogenesis of Rift Valley fever in rhesus monkeys: role of interferon response

  title={Pathogenesis of Rift Valley fever in rhesus monkeys: role of interferon response},
  author={John C. Morrill and Georgia Jennings and Alison Johnson and Thomas Michael Cosgriff and Paul H Gibbs and Clarence J. Peters},
  journal={Archives of Virology},
Rhesus monkeys inoculated intravenously with Rift Valley fever (RVF) virus presented clinical disease syndromes similar to human cases of RVF. All 17 infected monkeys had high-titered viremias but disease ranged from clinically inapparent to death. Three (18%) RVF virus-infected monkeys developed signs of hemorrhagic fever characterized by epistaxis, petechial to purpuric cutaneous lesions, anorexia, and vomiting prior to death. The 14 remaining monkeys survived RVF viral infection but, 7… CONTINUE READING
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