Pathogenesis of Parkinson's disease.

  title={Pathogenesis of Parkinson's disease.},
  author={David M A Mann and P. O. Yates},
  journal={Archives of neurology},
  volume={39 9},
Nucleolar volume and melanin pigment were measured in nerve cells of the substantia nigra in cases of idiopathic Parkinson's disease and in other cases of parkinsonism associated with cerebrovascular disease. In cerebrovascular parkinsonism, nucleolar volume is reduced by 16%, whereas melanin content is unchanged, reflecting local deficiencies in circulation on function of nerve cells, otherwise normal for age. In idiopathic parkinsonism, remaining cells are atrophied, and nucleolar volume is… CONTINUE READING