Pathogenesis of Paget Disease of Bone

  title={Pathogenesis of Paget Disease of Bone},
  author={Stuart H. Ralston and Robert Layfield},
  journal={Calcified Tissue International},
Paget disease of bone (PDB) is a common disease characterized by focal areas of increased and disorganized bone turnover. Some patients are asymptomatic, whereas others develop complications such as pain, osteoarthritis, fracture, deformity, deafness, and nerve compression syndromes. PDB is primarily caused by dysregulation of osteoclast differentiation and function, and there is increasing evidence that this is due, in part, to genetic factors. One of the most important predisposing genes is… CONTINUE READING
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