Pathogenesis of NUT midline carcinoma.

  title={Pathogenesis of NUT midline carcinoma.},
  author={Christopher A French},
  journal={Annual review of pathology},
NUT midline carcinoma (NMC), an aggressive form of squamous cell carcinoma, is defined by the presence of acquired chromosomal rearrangements involving NUT, usually BRD4-NUT fusion genes and, less commonly, NUT-variant fusion genes involving BRD3 or still-uncharacterized genes. Improved diagnostic tests reveal that although rare, NMCs occur in people of any age and may be indistinguishable from more common squamous cell carcinomas of adulthood. NMCs have simple karyotypes whose hallmark is… CONTINUE READING
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  • Cancer Res
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8 Excerpts

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  • Cancer Res
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