Pathogenesis of Murine Coronavirus in the Central Nervous System

  title={Pathogenesis of Murine Coronavirus in the Central Nervous System},
  author={Susan J. Bender and Susan R Weiss},
  journal={Journal of Neuroimmune Pharmacology},
Murine coronavirus (mouse hepatitis virus, MHV) is a collection of strains that induce disease in several organ systems of mice. Infection with neurotropic strains JHM and A59 causes acute encephalitis, and in survivors, chronic demyelination, the latter of which serves as an animal model for multiple sclerosis. The MHV receptor is a carcinoembryonic antigen-related cell adhesion molecule, CEACAM1a; paradoxically, CEACAM1a is poorly expressed in the central nervous system (CNS), leading to… CONTINUE READING
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