Pathogenesis of Inflammation. I. the Production of an Inflammatory Substance from Rabbit Granulocytes in Vitro and Its Relationship to Leucocyte Pyrogen.


Material obtained from the in vitro incubation of granulocytes from saline-induced peritoneal exudates of rabbits has been shown to produce inflammation and fever in rabbits. The supernatant material from cells incubated in saline has been termed granulocytic substance (GS) and is heat-labile. Its production is temperature dependent, occurring at 37 degrees… (More)