Pathogenesis of IgA nephropathy.

  title={Pathogenesis of IgA nephropathy.},
  author={Jonathan Barratt and John Feehally and Alice C Smith},
  journal={Seminars in nephrology},
  volume={24 3},
In IgA nephropathy (IgAN), there is dysregulation of the IgA response to a wide range of antigens. The dysregulation promotes synthesis of polymeric IgA1 (pIgA1) with physicochemical characteristics that favor mesangial deposition, including altered O-glycosylation of the hinge region. This may be the synthesis of IgA in the systemic compartment, which has the phenotype of mucosal IgA. There is not a change in IgA1 structure to an entirely abnormal form; rather, there is a shift that results in… CONTINUE READING


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