Pathogenesis of IBS: role of inflammation, immunity and neuroimmune interactions

  title={Pathogenesis of IBS: role of inflammation, immunity and neuroimmune interactions},
  author={Lena {\"O}hman and Magnus Simr{\'e}n},
  journal={Nature Reviews Gastroenterology \&Hepatology},
  • L. Öhman, M. Simrén
  • Published 26 January 2010
  • Medicine, Biology
  • Nature Reviews Gastroenterology &Hepatology
IBS is one of the most common functional gastrointestinal disorders worldwide and is thought to be the result of disturbed neural function along the brain–gut axis. The mechanisms behind this disturbance are not clear, but important roles for low-grade inflammation and immunological alterations in the development of symptoms compatible with IBS have become evident. The development of long-standing gastrointestinal symptoms after infectious gastroenteritis and patients with IBD in remission… 

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