Pathogenesis of Hypertension

  title={Pathogenesis of Hypertension},
  author={Suzanne Oparil and Mohammad Amin Zaman and David A Calhoun},
  journal={Annals of Internal Medicine},
Clinical Principles A clearer understanding of the pathogenesis of hypertension will probably lead to more highly targeted therapies and to greater reduction in hypertension-related cardiovascular disease morbidity than can be achieved with current empirical treatment. Physiologic Principles More than 90% of cases of hypertension do not have a clear cause. Hypertension clusters in families and results from a complex interaction of genetic and environmental factors. The hypertension-related… 

Salt and Hypertension Hypothesis - Still Relevant

The traditional view emphasized the centrality of the kidney and its malfunction in the development of hypertension, but the hypothesis that renal salt handling plays a role in hypertension has also been supported by studies which show that genetic mutations affect blood pressure in Mendelian or monogenic forms of human hypertension and hypotension.

Apparent treatment-resistant hypertension and chronic kidney disease: another cardiovascular-renal syndrome?

To identify patients at increased risk of cardiovascular (CV) outcomes, apparent treatment-resistant hypertension (aTRH) is defined as having a blood pressure above goal despite the use of 3 or more

Pathophysiology of essential hypertension: an update

Hypertension is caused by increased cardiac output and/or increased peripheral resistance and its pathogenesis involves alteration in ANS (autonomic nervous system) and likely in cortical-hypothalamic connections.


There is no direct description of HTN in Ayurveda but based on its clinical presentation and similarity between pathogenesis factors for hypertension can be correlated with Raktagata Vata and it is considered as Tridoshaja Vyadhi.

Hypertension and Atherosclerosis: Pathophysiology, Mechanisms and Benefits of BP Control

As emerging countries have improved sanitation and other basic public health measures, cardiovascular (CV) disease has or soon will become the most common cause of death, and hypertension will be its most common reversible risk factor, as it already is in the United States.

Hypertension and Exercise Training: Evidence from Clinical Studies.

This chapter will describe the classical and recent results on the beneficial effects of different modalities of exercise training in the cardiovascular system of human primary hypertension, focusing on the mechanisms influenced by exercise training which help to decrease blood pressure and improve the cardiovascularsystem.

The Difference of Endothelin-1 Levels in Hypertension Stage 1 , 2 and Non Hypertension Person

This research shows that the increasing levels of endothelin-1 is in a row with increasing of blood pressure in hypertension stage 1 and 2; and the increasing more clear and meaningful in the 50-75 year age of group.

Exercise and Blood Pressure Control in Hypertension

This chapter presents the pathophysiology, prevalence, and incidence of hypertension, and discusses new and emerging research on the effects of acute and chronic exercise on BP that has the potential to alter the way in which aerobic exercise is prescribed to prevent, treat, and control hypertension in the future.

Cardiovascular Autonomic Dysfunction in Chronic Kidney Disease: a Comprehensive Review

  • I. M. Salman
  • Medicine, Biology
    Current Hypertension Reports
  • 2015
Cardiovascular autonomic dysfunction is a major complication of chronic kidney disease (CKD), likely contributing to the high incidence of cardiovascular mortality in this patient population. In



Autonomic imbalance, hypertension, and cardiovascular risk.

Essential hypertension. Part I: definition and etiology.

This review of current concepts regarding the definition, etiology, and treatment of essential hypertension is intended to aid the clinician in identifying those individuals at high risk who need to undergo evaluation and treatment, as well as in selecting optimal treatment strategies for hypertensive patients with comorbid conditions and/or target organ damage.

Hypertension: A Companion to Brenner and Rector's The Kidney

A history of Clinical Hypertension from 1827-1970 and current Prescribing Practices, as well as new Interpretations of Blood Pressure: Importance of Pulse Pressure, show the need to consider evidence-based medicine.

Effects of antihypertensive drugs on vascular remodeling: do they predict outcome in response to antihypertensive therapy?

  • E. Schiffrin
  • Medicine, Biology
    Current opinion in nephrology and hypertension
  • 2001
Current evidence does not support the rational expectation that vasculoprotective antihypertensive agents will be associated with better outcomes in hypertensive patients, possibly because of limitations of these trials.

The evidence for a pathophysiologic significance of the sympathetic overactivity in hypertension.

  • S. Julius
  • Medicine, Biology
    Clinical and experimental hypertension
  • 1996
High sympathetic tone explains the pathophysiology of "pressure-independent" risk for premature coronary atherosclerosis in hypertension and for excess mortality/morbidity in patients who had already developed coronary heart disease.

Molecular genetics of human hypertension.

  • F. Luft
  • Biology, Medicine
    Journal of hypertension
  • 1998
To find new genes, novel approaches will be necessary, including searching for quantitative trait loci linked to blood pressure in normotensive persons, haplotype sharing methodology in trios and family units, the use of better study designs, and the investigation of isolated populations.

Hypertension and associated metabolic abnormalities--the role of insulin resistance and the sympathoadrenal system.

It is hypothesized that the metabolic abnormalities linked to the hypertension by a pathophysiologic process that involves the sympathoadrenal system and exerts influence on blood pressure and complications in many patients.

Characteristics of patients with uncontrolled hypertension in the United States.

Most cases of uncontrolled hypertension in the United States consist of isolated, mild systolic hypertension in older adults, most of whom have access to health care and relatively frequent contact with physicians.

Molecular basis of human hypertension: Role of angiotensinogen

Small artery remodeling in hypertension

It is shown that the available evidence points to important roles for blood flow and growth factors, in addition to blood pressure, as causes of resistance artery remodeling, and the relationship between vascular structure and blood pressure is discussed.