Pathogenesis of Gout
@article{Choi2005PathogenesisOG, title={Pathogenesis of Gout}, author={Hyon K. Choi and David B. Mount and Anthony M. Reginato}, journal={Annals of Internal Medicine}, year={2005}, volume={143}, pages={499-516} }
Clinical Principles The overall disease burden of gout is substantial and may be increasing. As more scientific data on the modifiable risk factors and comorbidities of gout become available, integration of these data into gout care strategies may become essential. Hyperuricemia and gout are associated with the insulin resistance syndrome and related comorbid conditions. Lifestyle modifications that are recommended for gout generally align with those for major chronic disorders (such as the…
875 Citations
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References
SHOWING 1-10 OF 167 REFERENCES
Renal transplant-associated hyperuricemia and gout.
- Medicine, BiologyJournal of the American Society of Nephrology : JASN
- 2000
This article will explore the metabolic basis of gout in allograft recipients, and the currently available methods for treating gout will be examined with particular emphasis on drug interactions and specific needs of the transplant patient.
Hyperlipidaemia in hyperuricaemia and gout
- MedicineAnnals of the rheumatic diseases
- 1998
No longer can it be assumed that there is a common aetiology for the hyperuricaemia in patients who present with an acute urate crystal arthropathy and refer to it as “primary gout”, unless you regard this concept as meaning a relatively poor renal clearance of urate in the presence of otherwise normal renal function.
Gout, diet, and the insulin resistance syndrome.
- MedicineThe Journal of rheumatology
- 2002
Although gout is one of the better understood of the rheumatic diseases, and certainly one the most gratifying to treat, a number of management issues, including the role of dietary measures, remain uncertain.
Gout: can management be improved?
- MedicineCurrent opinion in rheumatology
- 2001
A low carbohydrate, high protein and unsaturated fat diet was recommended for gouty patients since they all enhance insulin sensitivity and therefore may promote a reduction in serum uric acid levels.
The association between gout and nephrolithiasis: the National Health and Nutrition Examination Survey III, 1988-1994.
- MedicineAmerican journal of kidney diseases : the official journal of the National Kidney Foundation
- 2002
Showing an independent association between kidney stone disease and gout strongly suggests that they share common underlying pathophysiological mechanisms, which may lead to improved preventive strategies for both conditions.
Obesity, weight change, hypertension, diuretic use, and risk of gout in men: the health professionals follow-up study.
- MedicineArchives of internal medicine
- 2005
Higher adiposity and weight gain are strong risk factors for gout in men, while weight loss is protective.
Hyperuricemic nephropathies.
- Medicine, BiologyNephron
- 1999
Chronic asymptomatic hyperuricemia may predict the adverse cardiovascular consequences of insulin resistance, and may serve as an indicator of renal vascular disease or insulin resistance.
The interaction between uric acid level and other risk factors on the development of gout among asymptomatic hyperuricemic men in a prospective study.
- MedicineThe Journal of rheumatology
- 2000
Uric acid level is the key factor for prevention of gout and needs constant monitoring, and other contributing or possible etiologic factors such as alcohol consumption, diuretics use, and excess weight gain carry an increased risk of g out attack among patients with hyperuricemia.
Pathogenesis of Hypertension
- Medicine, BiologyAnnals of Internal Medicine
- 2003
The novel concept that structural and functional abnormalities in the vasculature, including endothelial dysfunction, increased oxidative stress, vascular remodeling, and decreased compliance, may antedate hypertension and contribute to its pathogenesis has gained support in recent years.