Pathogenesis of FOLFOX induced sinusoidal obstruction syndrome in a murine chemotherapy model

  title={Pathogenesis of FOLFOX induced sinusoidal obstruction syndrome in a murine chemotherapy model},
  author={Sian Robinson and Jelena Mann and Aphrodite Vasilaki and John C. Mathers and A. Yu. Burt and Fiona Oakley and Steve A. White and D. A. Mann},
  booktitle={Journal of hepatology},
BACKGROUND & AIMS Sinusoidal obstruction syndrome (SOS) following oxaliplatin based chemotherapy can have a significant impact on post-operative outcome following resection of colorectal liver metastases. To date no relevant experimental models of oxaliplatin induced SOS have been described. The aim of this project was to establish a rodent model which could be utilised to investigate mechanisms underlying SOS to aid the development of therapeutic strategies. METHODS C57Bl/6 mice, maintained… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 3 times. VIEW TWEETS


Publications citing this paper.
Showing 1-10 of 30 extracted citations

Magnesium isoglycyrrhizinate has hepatoprotective effects in an oxaliplatin-induced model of liver injury

International journal of molecular medicine • 2018
View 6 Excerpts
Highly Influenced

Protective effect of Korean red ginseng on oxaliplatin-mediated splenomegaly in colon cancer

Annals of surgical treatment and research • 2018
View 3 Excerpts
Highly Influenced


Publications referenced by this paper.
Showing 1-10 of 45 references

PAI-1 in tissue fibrosis.

Journal of cellular physiology • 2012

Similar Papers

Loading similar papers…