Pathogenesis of DNA repair-deficient cancers: a statistical meta-analysis of putative Real Common Target genes

@article{Woerner2003PathogenesisOD,
  title={Pathogenesis of DNA repair-deficient cancers: a statistical meta-analysis of putative Real Common Target genes},
  author={Stefan M. Woerner and Axel Benner and Christian Sutter and Marian Schiller and Yan P. Yuan and Gisela Keller and Peer Bork and Magnus von Knebel Doeberitz and Johannes F Gebert},
  journal={Oncogene},
  year={2003},
  volume={22},
  pages={2226-2235}
}
DNA mismatch repair deficiency is observed in about 15% of human colorectal, gastric, and endometrial tumors and in lower frequencies in a minority of other tumors thereby causing insertion/deletion mutations at short repetitive sequences, recognized as microsatellite instability (MSI). Evolution of tumors, including those with MSI, is a continuous process of mutation and selection favoring neoplastic growth. Mutations in microsatellite-bearing genes that promote tumor cell growth in general… CONTINUE READING