Pathogenesis of Borna disease in rats: immune-mediated viral ophthalmoencephalopathy causing blindness and behavioral abnormalities.

@article{Narayan1983PathogenesisOB,
  title={Pathogenesis of Borna disease in rats: immune-mediated viral ophthalmoencephalopathy causing blindness and behavioral abnormalities.},
  author={Opendra Narayan and Sibylle M Herzog and Knut Arvid Frese and H Scheefers and Rudolf Rott},
  journal={The Journal of infectious diseases},
  year={1983},
  volume={148 2},
  pages={305-15}
}
Borna disease virus is an unclassified agent that causes a rare but fatal encephalitis in horses in Germany. In experimental animals the virus causes acute fatal encephalitis in some instances and chronic encephalitis with abnormal behavior in others. In initial studies of the pathogenesis of the latter disease in rats, the virus was shown to replicate only in the nervous system, with the greatest concentration of infectivity in the cerebrum and eyes. Viral replication continued indefinitely in… CONTINUE READING

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