Pathogenesis of Age-Related Osteoporosis: Impaired Mechano-Responsiveness of Bone Is Not the Culprit

@article{Leppnen2008PathogenesisOA,
  title={Pathogenesis of Age-Related Osteoporosis: Impaired Mechano-Responsiveness of Bone Is Not the Culprit},
  author={Olli V Lepp{\"a}nen and Harri Siev{\"a}nen and Jarkko Jokihaara and Ilari Pajam{\"a}ki and P Kannus and Teppo L. N. J{\"a}rvinen},
  journal={PLoS ONE},
  year={2008},
  volume={3},
  pages={1547 - 1551}
}
BACKGROUND According to prevailing understanding, skeletal mechano-responsiveness declines with age and this apparent failure of the mechano-sensory feedback system has been attributed to the gradual bone loss with aging (age-related osteoporosis). The objective of this study was to evaluate whether the capacity of senescent skeleton to respond to increased loading is indeed reduced as compared to young mature skeleton. METHODS AND FINDINGS 108 male and 101 female rats were randomly assigned… CONTINUE READING

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