Pathogenesis in Menstrual Cycle‐Linked CNS Disorders

  title={Pathogenesis in Menstrual Cycle‐Linked CNS Disorders},
  author={T. B{\"a}ckstr{\"o}m and A. Andersson and L. Andr{\'e}e and V. Birzniece and M. Bixo and I. Bj{\"o}rn and D. Haage and M. Isaksson and I. Johansson and Charlott Lindblad and P. Lundgren and S. Nyberg and Inga-Stina {\"O}dmark and J. Str{\"o}mberg and I. Sundstr{\"o}m-Poromaa and S. Turkmen and G. Wahlstr{\"o}m and M. Wang and Anna-Carin Wihlb{\"a}ck and D. Zhu and Elisabeth Zingmark},
  journal={Annals of the New York Academy of Sciences},
  • T. Bäckström, A. Andersson, +18 authors Elisabeth Zingmark
  • Published 2003
  • Psychology, Medicine
  • Annals of the New York Academy of Sciences
  • Abstract: That 3alpha‐hydroxy‐5alpha/beta‐pregnane steroids (GABA steroids) have modulatory effects on the GABA‐A receptor is well known. In behavioral studies in animals high exogenous dosages give concentrations not usually reached in the brain under physiological conditions. Animal and human studies show that GABA‐A receptor‐positive modulators like barbiturates, benzodiazepines, alcohol, and allopregnanolone have a bimodal effect. In pharmacological concentrations they are CNS depressants… CONTINUE READING
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