Pathogenesis in Menstrual Cycle‐Linked CNS Disorders

  title={Pathogenesis in Menstrual Cycle‐Linked CNS Disorders},
  author={Torbj{\"o}rn B{\"a}ckstr{\"o}m and Agneta Andersson and L Andr{\'e}e and Vita Birzniece and Marie Bixo and Inger Bj{\"o}rn and David Haage and Monica Isaksson and Inga-Maj Johansson and Charlotte Lindblad and Per Lundgren and Sigrid Nyberg and Inga-Stina {\"O}dmark and Jessica Str{\"o}mberg and Inger Sundstr{\"o}m-Poromaa and Sahruh Turkmen and G{\"o}ran Wahlstr{\"o}m and Ming-de Wang and Anna‐Carin Wihlb{\"a}ck and Di Zhu and Elisabeth Zingmark},
  journal={Annals of the New York Academy of Sciences},
Abstract: That 3alpha‐hydroxy‐5alpha/beta‐pregnane steroids (GABA steroids) have modulatory effects on the GABA‐A receptor is well known. In behavioral studies in animals high exogenous dosages give concentrations not usually reached in the brain under physiological conditions. Animal and human studies show that GABA‐A receptor‐positive modulators like barbiturates, benzodiazepines, alcohol, and allopregnanolone have a bimodal effect. In pharmacological concentrations they are CNS depressants… 

GABAA Receptor-Modulating Steroids in Relation to Women’s Behavioral Health

In certain women, increased negative mood relates to the progesterone metabolite, allopregnanolone (allo), during the luteal phase of ovulatory menstrual cycles, the premenstrual dysphoric disorder (PMDD), and this effect can be induced by all GABAA receptor modulators in low concentrations whereas higher concentrations are calming.

Tolerance to allopregnanolone with focus on the GABA‐A receptor

It is shown that both acute and chronic tolerances can develop to the effects of allopregnanolone, and the exact mechanism of the allopreginolone tolerance phenomena remains unclear.

The role of ovarian hormone-derived neurosteroids on the regulation of GABAA receptors in affective disorders

GABAAR plasticity associated with alterations in neurosteroid levels represents a homeostatic compensatory mechanism to maintain an ideal level of inhibition to offset the potentiating effects of neurosteroids on GABAergic inhibition.

Does Interrelationship of Allopregnanolone and

This manuscript will bring you up to date on the interaction and function of these two neuroactive steroids during pregnancy and postpartum depression.

Disadaptive disorders in women: allopregnanolone, a sensitive steroid

  • F. BernardiN. Pluchino A. Genazzani
  • Psychology, Biology
    Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology
  • 2004
Observations suggest that fluctuations of allopregnanolone might be involved in the development, course and prognosis of some mental disorders in humans, and in particular women show a marked gender-related sensitivity to disadaptive disorders.

Neurosteroids and Affective Disorders in Women

The relation of neurosteroids with affective disorders in women and novel treatments in this regard are described in an understandable and synthesized review of the subject.

Does Interrelationship of Allopregnanolone andTetrahydrodeoxycorticosterone during Pregnancy and Postpartum Depression Exist? A Review of the Current Evidence

This manuscript will bring you up to date on the interaction and function of these two neuroactive steroids during pregnancy and postpartum depression.

Physiological Relevance of Pregnanolone Isomers and Their Polar Conjugates with Respect to the Gender, Menstrual Cycle and Pregnancy

5Ǐ/ǐ-Reduced progesterone metabolites (PM) including pregnanolone isomers (PI) and their polar conjugates (PIC), are efficient neuromodulators operating in a number of physiological and pathological



The Role of Hormones and Hormonal Treatments in Premenstrual Syndrome

SSRIs and substances inhibiting ovulation, such as gonadotrophin-releasing hormone (GnRH) agonists, have proven to be effective treatments and add-back hormone replacement therapy is recommended to avoid adverse effects when high dosages of GnRH agonists are sed.

Lack of influence of menstrual cycle and premenstrual syndrome diagnosis on pregnanolone pharmacokinetics

Pregnanolone pharmacokinetics do not differ between follicular and luteal phase of the menstrual cycle, nor between PMS patients and control subjects, and no differences in pharmacokinetic variables were detected between cycle phases.

Steroid hormone metabolites are barbiturate-like modulators of the GABA receptor.

Two metabolites of the steroid hormones progesterone and deoxycorticosterone are potent barbiturate-like ligands of the gamma-aminobutyric acid (GABA) receptor-chloride ion channel complex and potentiated the inhibitory actions of GABA in cultured rat hippocampal and spinal cord neurons, which may explain the ability of certain steroid hormones to rapidly alter neuronal excitability.

Neuroactive steroids and central nervous system disorders.