Pathogenesis beyond the cancer clone(s) in multiple myeloma.

  title={Pathogenesis beyond the cancer clone(s) in multiple myeloma.},
  author={Giada Bianchi and Nikhil C. Munshi},
  volume={125 20},
Over the past 4 decades, basic research has provided crucial information regarding the cellular and molecular biology of cancer. In particular, the relevance of cancer microenvironment (including both cellular and noncellular elements) and the concept of clonal evolution and heterogeneity have emerged as important in cancer pathogenesis, immunologic escape, and resistance to therapy. Multiple myeloma (MM), a cancer of terminally differentiated plasma cells, is emblematic of the impact of cancer… CONTINUE READING
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