Pathogenesis and vascular integrity of breast cancer brain metastasis.

  title={Pathogenesis and vascular integrity of breast cancer brain metastasis.},
  author={Weixin Lu and Corazon D. Bucana and Alan Jay Schroit},
  journal={International journal of cancer},
  volume={120 5},
Dogma dictates that brain metastasis originate from the proliferation of extravasated tumor cells and that the blood-brain barrier (BBB) prevents the delivery of chemotherapeutic drugs to the tumors. The purpose of this study was to clarify the relationship between tumor localization and progression and the involvement of BBB function in a murine model of breast cancer brain metastasis. Green fluorescent protein expressing MDA-MB435 breast cancer cells were injected into the left ventricle of… CONTINUE READING


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