Pathogenesis and therapeutic aspects of Crohn's disease.

  title={Pathogenesis and therapeutic aspects of Crohn's disease.},
  author={Warwick S. Selby},
  journal={Veterinary microbiology},
  volume={77 3-4},
Crohn's disease is a chronic, relapsing inflammatory condition affecting any part of the human gastrointestinal tract. It is characterised by transmural inflammation with deep ulceration, thickening of the bowel wall and fistula formation. The hallmark is the non-caseating granuloma. Clinical presentation depends upon the site of the inflammation. Pain and diarrhoea are frequent. Extraintestinal manifestations develop in up to 25% of patients and perianal disease is also frequent. The aetiology… CONTINUE READING
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