Pathogenesis and sepsis caused by organisms potentially utilized as biologic weapons: opportunities for targeted intervention.

@article{Hepburn2007PathogenesisAS,
  title={Pathogenesis and sepsis caused by organisms potentially utilized as biologic weapons: opportunities for targeted intervention.},
  author={Matthew J. Hepburn and Bret K Purcell and Jason Paragas},
  journal={Current drug targets},
  year={2007},
  volume={8 4},
  pages={
          519-32
        }
}
The microorganisms potentially utilized as biologic weapons have a variety of pathogenic mechanisms that lead to overwhelming infection, septic shock and death. Although many of these organisms have unique pathogenic attributes, the development of generic therapies for common pathways would be exceedingly useful as countermeasures. This review will examine the features of pathogenesis leading to sepsis for key biologic threat agents (causative agents of anthrax, plague, tularemia, smallpox and… CONTINUE READING