Pathogenesis and prevention of rheumatic disease: focus on preclinical RA and SLE

@article{Deane2014PathogenesisAP,
  title={Pathogenesis and prevention of rheumatic disease: focus on preclinical RA and SLE},
  author={Kevin D. Deane and Hani El-Gabalawy},
  journal={Nature Reviews Rheumatology},
  year={2014},
  volume={10},
  pages={212-228}
}
Established and emerging data demonstrate that a 'preclinical' period of disease precedes the onset of clinical rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), as well as other autoimmune rheumatic diseases (ARDs).This preclinical stage of development of disease is characterized by abnormalities in disease-related biomarkers before the onset of the clinically apparent signs and symptoms. Numerous genetic and environmental risk factors for ARDs have also been identified, and… CONTINUE READING

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