Pathogenesis and natural history of osteonecrosis.

  title={Pathogenesis and natural history of osteonecrosis.},
  author={Yehudith Assouline-Dayan and Christopher Chang and Adam Greenspan and Yehuda Shoenfeld and M Eric Gershwin},
  journal={Seminars in arthritis and rheumatism},
  volume={32 2},
BACKGROUND AND OBJECTIVES Osteonecrosis (avascular necrosis) is a relatively common disorder seen by both rheumatologists and orthopedic surgeons. The vast majority of cases are secondary to trauma. However, for non-traumatic cases, there often remains a diagnostic challenge in defining the cause of bone death. The goal of this article is to review data extensively in the medical literature with respect to the pathogenesis of osteonecrosis, its natural history, and treatment. METHODS A review… CONTINUE READING
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