Pathogenesis and management of iron toxicity in thalassemia.

  title={Pathogenesis and management of iron toxicity in thalassemia.},
  author={Chaim M Hershko},
  journal={Annals of the New York Academy of Sciences},
In thalassemia major, iron overload is the joint outcome of multiple blood transfusions and an inappropriately increased iron absorption associated with ineffective erythropoiesis. Threshold values for iron toxicity are a liver iron concentration exceeding 440 mmoles/g dry weight, serum ferritin >2500 ng/mL, DFO urinary iron excretion >20 mg/day, and transferrin saturation >75%. The outpouring of catabolic iron that exceeds the iron-carrying capacity of transferrin results in the emergence of… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 49 extracted citations


Publications referenced by this paper.
Showing 1-10 of 42 references

Similar Papers

Loading similar papers…