Pathogenesis and management of iron toxicity in thalassemia.

@article{Hershko2010PathogenesisAM,
  title={Pathogenesis and management of iron toxicity in thalassemia.},
  author={Chaim M Hershko},
  journal={Annals of the New York Academy of Sciences},
  year={2010},
  volume={1202},
  pages={1-9}
}
In thalassemia major, iron overload is the joint outcome of multiple blood transfusions and an inappropriately increased iron absorption associated with ineffective erythropoiesis. Threshold values for iron toxicity are a liver iron concentration exceeding 440 mmoles/g dry weight, serum ferritin >2500 ng/mL, DFO urinary iron excretion >20 mg/day, and transferrin saturation >75%. The outpouring of catabolic iron that exceeds the iron-carrying capacity of transferrin results in the emergence of… CONTINUE READING

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