Pathogenesis and management of abnormal puberty.

  • Nancy J Hopwood
  • Published 1985 in Special topics in endocrinology and metabolism
In the prepubertal child, the hypothalamic-pituitary-gonadal (H-P-G) axis is functional and extremely sensitive to negative feedback inhibition by low circulating levels of sex steroids. This feedback system may be under the control of unknown CNS inhibitory mechanisms. Clinical signs of puberty are preceded by increased pulsatile secretion of hypothalamic… CONTINUE READING