Pathogenesis and genetics of pre-eclampsia

  title={Pathogenesis and genetics of pre-eclampsia},
  author={J. Roberts and D. Cooper},
  journal={The Lancet},
  • J. Roberts, D. Cooper
  • Published 2001
  • Medicine
  • The Lancet
  • After more than a century of intensive research, pre-eclampsia and eclampsia remain an enigmatic set of conditions. Aberration of the interaction between placental and maternal tissue is probably the primary cause, but the exact nature of the differences from normal pregnancy remain elusive. In this review attempts to understand the sequence of physiological changes have concentrated on vascular endothelium and oxidative stress issues. There are genetic components to susceptibility, but the… CONTINUE READING
    1,221 Citations

    Topics from this paper

    Paper Mentions

    Interventional Clinical Trial
    - Mild pre-eclampsia represents 75% of cases with pre-eclampsia, possible progression to severe pre-eclampsia makes mild pre-eclampsia a serious problem that requires attention… Expand
    ConditionsPre-Eclampsia; Mild
    Pre-eclampsia--still a disease of theories.
    • D. Schlembach
    • Biology, Medicine
    • Fukushima journal of medical science
    • 2003
    • 60
    Pre-eclampsia and thrombophilia.
    • J. Said, G. Dekker
    • Medicine
    • Best practice & research. Clinical obstetrics & gynaecology
    • 2003
    • 29
    Genetic studies of pre-eclampsia
    • 1
    Hypertensive diseases and eclampsia
    • 51
    The Genetic Aspects of Pre-eclampsia: Achievements and Limitations
    • 33
    Developmental Biology: Frontiers for Clinical Genetics
    The genetics of pre‐eclampsia: a feto‐placental or maternal problem?
    • 123
    • Highly Influenced
    Pre-eclampsia: the pivotal role of the placenta in its pathophysiology and markers for early detection
    • 71


    Genetics of Pre-Eclampsia
    • 94
    Genetic control of susceptibility to eclampsia and miscarriage
    • 109
    Genetic control of severe pre-eclampsia.
    • 82
    • PDF
    A molecular variant of angiotensinogen associated with preeclampsia
    • 502
    The L10F mutation of angiotensinogen is rare in pre‐eclampsia
    • 11