Pathogenesis, detection and treatment of Achilles tendon xanthomas

@article{Tsouli2005PathogenesisDA,
  title={Pathogenesis, detection and treatment of Achilles tendon xanthomas},
  author={S. Tsouli and D. Kiortsis and M. Argyropoulou and D. Mikhailidis and M. Elisaf},
  journal={European Journal of Clinical Investigation},
  year={2005},
  volume={35}
}
Tendon xanthomatosis often accompanies familial hypercholesterolaemia, but it can also occur in other pathologic states. Achilles tendons are the most common sites of tendon xanthomas. Low‐density lipoprotein (LDL) derived from the circulation accumulates into tendons. The next steps leading to the formation of Achilles tendon xanthomas (ATX) are the transformation of LDL into oxidized LDL (oxLDL) and the active uptake of oxLDL by macrophages within the tendons. Although physical examination… Expand
An exceptional case of xanthomatous infiltration of the musculoskeletal and integumentary systems
TLDR
The radiographic and MR imaging descriptions of xanthomas in this report further add to the existing literature by helping to identify imaging characteristics of this multifocal systemic disease. Expand
Association of Achilles tendon thickness and LDL-cholesterol levels in patients with hypercholesterolemia
TLDR
ATT might serve as a valuable auxiliary diagnostic index for hypercholesterolemia and used for the assessment and management of cardiovascular disease. Expand
Tendon xanthomas: Not always familial hypercholesterolemia.
TLDR
The case presented here is of a 48-year old male with large tendon xanthomas attributable to CTX, a rare, recessive disorder caused by mutations in the CYP27A1 gene that is associated with neurologic symptoms and a reduced life expectancy. Expand
Xanthomas: clinical and pathophysiological relations.
TLDR
Thorough familiarity with the clinical presentation of xanthomas helps in the diagnosis and follow-up of different forms of dyslipidemia, and xanthelasma palpebrarum, the most prevalent form of xantha, is connected with increased risk of atherothrombotic disease independently of conventional cardiovascular risk factors. Expand
Can Achilles tendon xanthoma be distinguished from Achilles tendinopathy using Dixon method MRI? A cross-sectional exploratory study
TLDR
MRI-derived measures of Achilles tendon fat content may be able to distinguish xanthomas from control and tendinopathic tissue, and the Dixon method MRI warrants further evaluation in an adequately powered study to develop and test clinically relevant diagnostic thresholds. Expand
A Rare Case of Bilateral Achilles Tendon Xanthomas in a Teenager, Successfully Treated with Tendon Sparing Technique
Background Xanthoma of the Achilles tendon, even though being benign, is a surgically challenging orthopaedic condition. Causality is believed to be due to a pathological error in the metabolism ofExpand
Cholesterol level in non-insertional Achilles tendonopathy.
TLDR
Measurement of cholesterol in all patients presenting with achillodynia does not seem to be justified but the literature suggests that it should probably be considered in patients with bilateral extensive disease or those who give a history of intermittent episodes of severe pain lasting a few days. Expand
Achilles tendon xanthomas are associated with the presence and burden of subclinical coronary atherosclerosis in heterozygous familial hypercholesterolemia: A pilot study.
TLDR
It is found that Achilles tendon xanthomas are independently associated with the extension of subclinical coronary atherosclerosis quantified by tomographic scores in FH patients. Expand
Achilles Tendon Ultrasonography for Diagnosis of Familial Hypercholesterolemia Among Japanese Subjects.
BACKGROUND Difficulty in detecting and measuring Achilles tendon (AT) xanthomas may be responsible for underdiagnosis of familial hypercholesterolemia (FH). We aimed to determine a cutoff value forExpand
Adverse reactions of Achilles tendon xanthomas in three hypercholesterolemic patients after treatment intensification with niacin and bile acid sequestrants.
TLDR
Clinicians should be aware of this phenomenon in patients after intensifying lipid treatments, especially with the use of niacin in patients with familial hypercholesterolemia, and provide clues to new pharmacologic effects in cholesterol-infiltrated tissues. Expand
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TLDR
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TLDR
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TLDR
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TLDR
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