Pathogen resistance and genetic variation at MHC loci.

  • Philip W Hedrick
  • Published 2002 in
    Evolution; international journal of organic…
Balancing selection in the form of heterozygote advantage, frequency-dependent selection, or selection that varies in time and/or space, has been proposed to explain the high variation at major histocompatibility complex (MHC) genes. Here the effect of variation of the presence and absence of pathogens over time on genetic variation at multiallelic loci is… (More)