Pathogen-related differences in the abundance of presented antigen are reflected in CD4+ T cell dynamic behavior and effector function in the lung.

@article{TorabiParizi2014PathogenrelatedDI,
  title={Pathogen-related differences in the abundance of presented antigen are reflected in CD4+ T cell dynamic behavior and effector function in the lung.},
  author={Parizad Torabi-Parizi and Nienke Vrisekoop and Wolfgang Kastenmuller and Michael Y Gerner and Jackson G. Egen and Ronald N. Germain},
  journal={Journal of immunology},
  year={2014},
  volume={192 4},
  pages={
          1651-1660
        }
}
Exposure to pathogens in the periphery elicits effector T cell differentiation in local lymph nodes followed by migration of activated T cells to and within the infected site. However, the relationships among pathogen abundance, Ag display on MHC molecules, effector T cell dynamics, and functional responses at the infected sites are incompletely characterized. In this study, we compared CD4(+) T cell effector dynamics and responses during pulmonary mycobacterial infection versus acute influenza… CONTINUE READING
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