Pathogen effector recognition-dependent association of NRG1 with EDS1 and SAG101 in TNL receptor immunity

@article{Sun2020PathogenER,
  title={Pathogen effector recognition-dependent association of NRG1 with EDS1 and SAG101 in TNL receptor immunity},
  author={Xinhua Sun and Dmitry Lapin and Joanna Marie Feehan and Sara Christina Stolze and Katharina Kramer and Joram A. Dongus and Jakub Rzemieniewski and Servane Blanvillain-Baufum{\'e} and Anne Harzen and Jaqueline Bautor and Paul Derbyshire and Frank L. H. Menke and Iris Finkemeier and Hirofumi Nakagami and Jonathan D. G. Jones and Jane E. Parker},
  journal={Nature Communications},
  year={2020},
  volume={12}
}
Plants utilise intracellular nucleotide-binding, leucine-rich repeat (NLR) immune receptors to detect pathogen effectors and activate local and systemic defence. NRG1 and ADR1 “helper” NLRs (RNLs), cooperate with enhanced disease susceptibility 1 (EDS1), senescence-associated gene 101 (SAG101) and phytoalexin-deficient 4 (PAD4) lipase-like proteins to mediate signalling from TIR domain NLR receptors (TNLs). However, the mechanism of RNL/EDS1-family protein cooperation is poorly understood. Here… 
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