Pathogen destruction versus intracellular survival: the role of lipids as phagosomal fate determinants.

@article{Steinberg2008PathogenDV,
  title={Pathogen destruction versus intracellular survival: the role of lipids as phagosomal fate determinants.},
  author={Benjamin Ethan Steinberg and Sergio Grinstein},
  journal={The Journal of clinical investigation},
  year={2008},
  volume={118 6},
  pages={2002-11}
}
Phagocytosis is a key component of the innate immune response and of the clearance of apoptotic bodies. Phagosome formation and subsequent maturation require extensive cytoskeletal rearrangement and precisely choreographed vesicular fusion and fission events. The objectives of this review are to highlight the functional importance of lipids in the phagocytic process, to discuss how pathogenic microorganisms can in some cases manipulate host lipid metabolism to either co-opt or disrupt phagosome… CONTINUE READING

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