Pathogen corruption and site-directed recombination at a plant disease resistance gene cluster.

@article{Nagy2008PathogenCA,
  title={Pathogen corruption and site-directed recombination at a plant disease resistance gene cluster.},
  author={Ervin D. Nagy and Jeffrey Bennetzen},
  journal={Genome research},
  year={2008},
  volume={18 12},
  pages={1918-23}
}
The Pc locus of sorghum (Sorghum bicolor) determines dominant sensitivity to a host-selective toxin produced by the fungal pathogen Periconia circinata. The Pc region was cloned by a map-based approach and found to contain three tandemly repeated genes with the structures of nucleotide binding site-leucine-rich repeat (NBS-LRR) disease resistance genes. Thirteen independent Pc-to-pc mutations were analyzed, and each was found to remove all or part of the central gene of the threesome. Hence… CONTINUE READING

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