Pathogen activators of plasminogen.

@article{Verhamme2015PathogenAO,
  title={Pathogen activators of plasminogen.},
  author={Ingrid M. Verhamme and Peter Panizzi and Paul E. Bock},
  journal={Journal of thrombosis and haemostasis : JTH},
  year={2015},
  volume={13 Suppl 1},
  pages={
          S106-14
        }
}
Group A streptococci (GAS) express soluble and surface-bound virulence factors. Secreted streptokinase (SK) allelic variants exhibit varying abilities to activate host plasminogen (Pg), and GAS pathogenicity is associated with Pg activation and localization of the resulting plasmin (Pm) on the bacterial surface to promote dissemination. The various mechanisms by which GAS usurp the host proteolytic system are discussed, including the molecular sexuality mechanism of conformational activation of… CONTINUE READING
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