Pathogen Recognition and Innate Immunity

@article{Akira2006PathogenRA,
  title={Pathogen Recognition and Innate Immunity},
  author={Shizuo Akira and Satoshi Uematsu and Osamu Takeuchi},
  journal={Cell},
  year={2006},
  volume={124},
  pages={783-801}
}
Microorganisms that invade a vertebrate host are initially recognized by the innate immune system through germline-encoded pattern-recognition receptors (PRRs). Several classes of PRRs, including Toll-like receptors and cytoplasmic receptors, recognize distinct microbial components and directly activate immune cells. Exposure of immune cells to the ligands of these receptors activates intracellular signaling cascades that rapidly induce the expression of a variety of overlapping and unique… Expand

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This review focuses on the functions of PRRs in innate immunity and their downstream signaling cascades and identifies cytoplasmic PRRs to detect pathogens that have invaded cytosols. Expand
PRRs in pathogen recognition
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This review focuses on the pathogen recognition of PRRs in innate immunity, and identifies cytoplasmic PRRs which detect pathogens that have invaded the cytosol. Expand
Pathogen recognition by innate receptors
  • Y. Kumagai, O. Takeuchi, S. Akira
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  • 2008
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This review will describe pathogen recognition by Toll-like receptors, signaling pathways, and their in vivo roles in innate antiviral immunity. Expand
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The present review will discuss the recent progress in the study of pathogen recognition by TLRs, RLRs and NLRs and their signalling pathways. Expand
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Recent findings on bacterial recognition by Toll-like receptors and NLRs and the signaling pathways activated by these sensors are reviewed. Expand
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The molecular pathways initiated in response to pathogens are presented to understand innate immune activity and the development of precise methods of preventing and treating infection at the molecular level. Expand
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TLDR
This review discusses the recent developments in microbial recognition by Toll-like receptors (TLRs) and intracellular nucleic acid sensors and the signaling pathways initiated by them. Expand
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The role of PRRs, their signaling pathways, and how they control inflammatory responses are discussed. Expand
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Recent insights into pathogen sensing by PRRs are summarized and specific signaling pathways that lead to expression of genes that tailor immune responses to particular microbes are summarized. Expand
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References

SHOWING 1-10 OF 155 REFERENCES
NLRs join TLRs as innate sensors of pathogens.
TLDR
The function and biology of a new family of PRRs, the NACHT-LRRs (NLRs), which include both nucleotide-binding oligomerization domains (NODs) and NALPs, are discussed, and some intriguing similarities between NLRs and TLRs are underlined that emphasize the role of NLRs as a complementary system for host-microbe interactions. Expand
Innate immune recognition.
TLDR
Microbial recognition by Toll-like receptors helps to direct adaptive immune responses to antigens derived from microbial pathogens to distinguish infectious nonself from noninfectious self. Expand
Toll-like receptor pathways in the immune responses to mycobacteria.
TLDR
Evidence from in vitro and in vivo investigations demonstrates TLR-dependent activation of innate immune response, while the induction of adaptive immunity to mycobacteria may be TLR independent. Expand
Toll-like receptor signalling
TLDR
Rapid progress that has recently improved the understanding of the molecular mechanisms that mediate TLR signalling is reviewed. Expand
Recognition of fungal pathogens by toll-like receptors.
TLDR
Recent data suggest that TLRs offer escape mechanisms to certain pathogenic microorganisms, especially through TLR2-driven induction of antiinflamatory cytokines, and provide hope for designing new therapeutical approaches to fungal infections. Expand
Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus
TLDR
A common receptor activation pathway can initiate innate immune responses to both bacterial and viral pathogens. Expand
The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors.
TLDR
The data suggest that TLRs sample the contents of the phagosome independent of the nature of the contents, and can establish a combinatorial repertoire to discriminate among the large number of pathogen-associated molecular patterns found in nature. Expand
The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5
TLDR
It is reported that mammalian TLR5 recognizes bacterial flagellin from both Gram-positive and Gram-negative bacteria, and that activation of the receptor mobilizes the nuclear factor NF-κB and stimulates tumour necrosis factor-α production, and the data suggest thatTLR5, a member of the evolutionarily conserved Toll-like receptor family, has evolved to permit mammals specifically to detect flageLLated bacterial pathogens. Expand
Inferences, questions and possibilities in Toll-like receptor signalling
TLDR
The Toll-like receptors are the key proteins that allow mammals — whether immunologically naive or experienced — to detect microbes and many inflammatory processes, both sterile and infectious, may depend on TLR signalling. Expand
TLR11 Activation of Dendritic Cells by a Protozoan Profilin-Like Protein
TLDR
A profilin-like molecule from the protozoan parasite Toxoplasma gondii is identified that generates a potent interleukin-12 (IL-12) response in murine DCs that is dependent on myeloid differentiation factor 88 and is the first chemically defined ligand for this TLR. Expand
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