Pathogen Recognition and Innate Immunity

@article{Akira2006PathogenRA,
  title={Pathogen Recognition and Innate Immunity},
  author={Shizuo Akira and Satoshi Uematsu and Osamu Takeuchi},
  journal={Cell},
  year={2006},
  volume={124},
  pages={783-801}
}
Microorganisms that invade a vertebrate host are initially recognized by the innate immune system through germline-encoded pattern-recognition receptors (PRRs). Several classes of PRRs, including Toll-like receptors and cytoplasmic receptors, recognize distinct microbial components and directly activate immune cells. Exposure of immune cells to the ligands of these receptors activates intracellular signaling cascades that rapidly induce the expression of a variety of overlapping and unique… Expand
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Citation Type

Toll-like receptors and innate immunity
TLDR
This review focuses on the functions of PRRs in innate immunity and their downstream signaling cascades and identifies cytoplasmic PRRs to detect pathogens that have invaded cytosols. Expand
PRRs in pathogen recognition
TLDR
This review focuses on the pathogen recognition of PRRs in innate immunity, and identifies cytoplasmic PRRs which detect pathogens that have invaded the cytosol. Expand
Pathogen recognition by innate receptors
  • Y. Kumagai, O. Takeuchi, S. Akira
  • Medicine, Biology
  • Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy
  • 2008
TLDR
This review will describe pathogen recognition by Toll-like receptors, signaling pathways, and their in vivo roles in innate antiviral immunity. Expand
Pathogen recognition in the innate immune response.
TLDR
The present review will discuss the recent progress in the study of pathogen recognition by TLRs, RLRs and NLRs and their signalling pathways. Expand
Recognition of bacterial infection by innate immune sensors
TLDR
Recent findings on bacterial recognition by Toll-like receptors and NLRs and the signaling pathways activated by these sensors are reviewed. Expand
[Molecular mechanisms associated with recognition of pathogens by receptors of innate immunity].
TLDR
The molecular pathways initiated in response to pathogens are presented to understand innate immune activity and the development of precise methods of preventing and treating infection at the molecular level. Expand
Microbial sensing by Toll-like receptors and intracellular nucleic acid sensors.
TLDR
This review discusses the recent developments in microbial recognition by Toll-like receptors (TLRs) and intracellular nucleic acid sensors and the signaling pathways initiated by them. Expand
Host-microbe interactions: innate pattern recognition of fungal pathogens.
The recognition of fungi is mediated by germline pattern recognition receptors (PRRs) such as Toll-like receptors and lectin receptors that interact with conserved structures of the microorganisms,… Expand
Pattern Recognition Receptors and Inflammation
TLDR
The role of PRRs, their signaling pathways, and how they control inflammatory responses are discussed. Expand
The roles of TLRs, RLRs and NLRs in pathogen recognition.
TLDR
Recent insights into pathogen sensing by PRRs are summarized and specific signaling pathways that lead to expression of genes that tailor immune responses to particular microbes are summarized. Expand
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