10,396 Citations
Toll-like receptors and innate immunity
- BiologyJournal of Molecular Medicine
- 2006
This review focuses on the functions of PRRs in innate immunity and their downstream signaling cascades and identifies cytoplasmic PRRs to detect pathogens that have invaded cytosols.
PRRs in pathogen recognition
- BiologyCentral European Journal of Biology
- 2006
This review focuses on the pathogen recognition of PRRs in innate immunity, and identifies cytoplasmic PRRs which detect pathogens that have invaded the cytosol.
Pathogen recognition by innate receptors
- BiologyJournal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy
- 2008
This review will describe pathogen recognition by Toll-like receptors, signaling pathways, and their in vivo roles in innate antiviral immunity.
Pathogen recognition in the innate immune response.
- BiologyThe Biochemical journal
- 2009
The present review will discuss the recent progress in the study of pathogen recognition by TLRs, RLRs and NLRs and their signalling pathways.
Recognition of bacterial infection by innate immune sensors
- BiologyCritical reviews in microbiology
- 2013
Recent findings on bacterial recognition by Toll-like receptors and NLRs and the signaling pathways activated by these sensors are reviewed.
[Molecular mechanisms associated with recognition of pathogens by receptors of innate immunity].
- BiologyPostepy higieny i medycyny doswiadczalnej
- 2009
The molecular pathways initiated in response to pathogens are presented to understand innate immune activity and the development of precise methods of preventing and treating infection at the molecular level.
Microbial sensing by Toll-like receptors and intracellular nucleic acid sensors.
- BiologyCold Spring Harbor perspectives in biology
- 2014
This review discusses the recent developments in microbial recognition by Toll-like receptors (TLRs) and intracellular nucleic acid sensors and the signaling pathways initiated by them.
Host-microbe interactions: innate pattern recognition of fungal pathogens.
- BiologyCurrent opinion in microbiology
- 2008
The roles of TLRs, RLRs and NLRs in pathogen recognition.
- BiologyInternational immunology
- 2009
Recent insights into pathogen sensing by PRRs are summarized and specific signaling pathways that lead to expression of genes that tailor immune responses to particular microbes are summarized.
References
SHOWING 1-10 OF 165 REFERENCES
Innate immune recognition.
- BiologyAnnual review of immunology
- 2002
Microbial recognition by Toll-like receptors helps to direct adaptive immune responses to antigens derived from microbial pathogens to distinguish infectious nonself from noninfectious self.
Toll-like receptor signalling
- BiologyNature Reviews Immunology
- 2004
Rapid progress that has recently improved the understanding of the molecular mechanisms that mediate TLR signalling is reviewed.
Toll-like receptor pathways in the immune responses to mycobacteria.
- BiologyMicrobes and infection
- 2004
Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus
- BiologyNature Immunology
- 2000
A common receptor activation pathway can initiate innate immune responses to both bacterial and viral pathogens.
A Toll-like Receptor That Prevents Infection by Uropathogenic Bacteria
- BiologyScience
- 2004
A member of the mammalian TLR family, TLR11, is reported that displays a distinct pattern of expression in macrophages and liver, kidney, and bladder epithelial cells, indicating a potentially important role in preventing infection of internal organs of the urogenital system.
Recognition of fungal pathogens by Toll-like receptors
- BiologyEuropean Journal of Clinical Microbiology and Infectious Diseases
- 2004
New data suggest that TLRs offer escape mechanisms to certain pathogenic microorganisms, especially through TLR2-driven induction of anti-inflammatory cytokines, and the study of TLRs remains one of the most active areas of research in the field of fungal infections.
The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors.
- BiologyProceedings of the National Academy of Sciences of the United States of America
- 2000
The data suggest that TLRs sample the contents of the phagosome independent of the nature of the contents, and can establish a combinatorial repertoire to discriminate among the large number of pathogen-associated molecular patterns found in nature.
The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5
- BiologyNature
- 2001
It is reported that mammalian TLR5 recognizes bacterial flagellin from both Gram-positive and Gram-negative bacteria, and that activation of the receptor mobilizes the nuclear factor NF-κB and stimulates tumour necrosis factor-α production, and the data suggest thatTLR5, a member of the evolutionarily conserved Toll-like receptor family, has evolved to permit mammals specifically to detect flageLLated bacterial pathogens.
Inferences, questions and possibilities in Toll-like receptor signalling
- BiologyNature
- 2004
The Toll-like receptors are the key proteins that allow mammals — whether immunologically naive or experienced — to detect microbes and many inflammatory processes, both sterile and infectious, may depend on TLR signalling.