Pathogen Entrapment by Transglutaminase—A Conserved Early Innate Immune Mechanism

@article{Wang2010PathogenEB,
  title={Pathogen Entrapment by Transglutaminase—A Conserved Early Innate Immune Mechanism},
  author={Zhi W Wang and C. Wilhelmsson and P. Hyr{\vs}l and Torsten G. Loof and P. Dobe{\vs} and M. Klupp and O. Loseva and M. M{\"o}rgelin and Jennifer M. Ikl{\'e} and R. Cripps and H. Herwald and U. Theopold},
  journal={PLoS Pathogens},
  year={2010},
  volume={6}
}
Clotting systems are required in almost all animals to prevent loss of body fluids after injury. Here, we show that despite the risks associated with its systemic activation, clotting is a hitherto little appreciated branch of the immune system. We compared clotting of human blood and insect hemolymph to study the best-conserved component of clotting systems, namely the Drosophila enzyme transglutaminase and its vertebrate homologue Factor XIIIa. Using labelled artificial substrates we observe… Expand
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